aladdin 阿拉丁 N408309 尼拉帕尼甲苯磺酸盐 1038915-73-9 10mM in DMSO

中文名：尼拉帕尼甲苯磺酸盐

英文名：Niraparib (MK-4827) tosylate

英文别名：Niraparib tosylate, MK 4827 tosylate, ZEJULA;2H-​Indazole-​7-​carboxamide, 2-​[4-​(3S)​-​3-​piperidinylphenyl]​-​, 4-​methylbenzenesulfona​te (1:1)

纯度：10mM in DMSO

货号：N408309

包装：1ml

Cas号：1038915-73-9

存储温度：-80℃储存

产品介绍：

Information

Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor ofPARP1/PARP2withIC50of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage,apoptosis, and cell death.
In vitro

Micromolar concentrations of niraparib radiosensitizes tumor cell lines derived from lung, breast, and prostate cancers independently of their p53 status but not cell lines derived from normal tissues. Niraparib also sensitizes tumor cells to H2O2 and converts H2O2-induced single strand breaks (SSBs) into DSBs during DNA replication.

In vivo

MK-4827 strongly enhances the effect of radiation on a variety of human tumor xenografts, both p53 wild type and p53 mutant. MK-4827 reduces PAR levels in tumors by 1 h after administration which persisted for up to 24 h. In vivo treatment with MK-4827 and radiation prolonged survival (p<0.01) compared to single modalities. In vivo superiority of MK-4827 plus radiation is further documented by significant elevations of cleaved caspase-3 and γ-H2AX in tumors from the combination group compared to single modality cohorts.
Cell Data

cell lines：

Concentrations：50 nM

Incubation Time：24 h

Powder Purity:≥99%

查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/N408309.html