Maintains anti-proliferative activity against human malignant cell strains.
ChEBI: A labdane diterpenoid in which the labdane skeleton has double bonds at positions 8(17) and 14 and carries an R-hydroxy group at position 13.
By extraction of cornrninuted wood
of Dacrydium biforme, a tree indigenous to
New Zealand, with alcohol or Acetone. The
extract is neutralized with alkali, and the
crude Manool may be recrystallized.
IC50 (μg/mL): 49.3 (V79), 15.6 (B16F10),17.1 (MCF-7), 6.7 (HeLa), 28.5 (HepG2),9.6 (MO59 J), 6.7 (U343), 13.1 (U251)(de Oliveira et al. 2016)
