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Veliparib Structure

Veliparib

Chemical Properties

Boiling point 579.0±40.0 °C(Predicted)
Density  1.274
storage temp.  Store at -20°C
solubility  insoluble in H2O; ≥10.6 mg/mL in EtOH with ultrasonic; ≥6.11 mg/mL in DMSO
form  solid
pka 9.22±0.30(Predicted)
color  White to off-white
CAS DataBase Reference 912444-00-9
Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.

Usage And Synthesis

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