Pentamide-6, or Hexapeptide-11, was originally isolated from Saccharomyces yeast fermentation.
Pentamide-6 directly affects dermal cell senescence by downregulating key genes involved in apoptosis.
The cellular proteins ataxia telangiectasia mutated (ATM) and p53 have been shown to be hyperactive
in degenerative aging pathologies, leading to cellular senescence. Senescent cells in skin can
cause dermal thinning, loss of subcutaneous fat, decreased hair growth, and slower wound healing.
Pentamide-6 is a hexapeptide with the structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP). This oligopeptide
helps promote younger looking skin by reversibly downregulating ATMP and p53 at peptide
concentrations of 0.1%–1.0%. By targeting the cellular aging process, FVAPFP has been shown to
modulate senescence in both intrinsically and extrinsically aged fibroblasts, as well as extrinsically
aged dermal papillae cells in vitro. This signal oligopeptide has been shown to increase fibrillogenesis
through growth factors, and ECPs increase transmembrane and cell shock proteins, and promote
hair growth. A clinical trial conducted on 25 subjects showed its ability to increase skin elasticity and
reduce deformity in facial skin.
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.
Hexapeptide-11 reduces the appearance of fine lines and wrinkles, making this an excellent addition to all kinds of skin care and anti-aging products. It has a unique set of amino acids that help to manipulate collagen levels and boost elasticity in the skin.
Hexapeptide-11 promote the fibroblast to produce collagen and elastin,enhance skin elasticity and firmness, fadeout the fine wrinkle.Its recommended dosage is 0.5~3%.
Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes. Moreover, it promoted increased nuclear accumulation of Nrf2; higher expression levels of proteasomal protein subunits and increased proteasome peptidase activities. In line with these findings we noted that Hexapeptide-11 conferred significant protection in fibroblasts against oxidative-stress-mediated premature cellular senescence, while at in vivo skin deformation assays in human subjects it improved skin elasticity.
