普罗加比
普罗加比 性质
| 熔点 | 133-135°; mp 142.5° (Kaplan, J. Med. Chem.) |
|---|---|
| 沸点 | 525.4±50.0 °C(Predicted) |
| 密度 | 1.2822 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 氯仿（微溶超声处理）、DMSO、甲醇（微溶超声处理） |
| 酸度系数(pKa) | pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate) |
| 形态 | 固体 |
| 颜色 | 浅黄色至厚黄色 |
| 水溶解性 | 37.16mg/L(37 ºC) |
| CAS 数据库 | 62666-20-0 |
普罗加比 用途与合成方法
GABA receptor
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide.
普罗加比 化学药品说明书
普罗加比 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-08-19 | HY-A0173 | 普罗加比 | 62666-20-0 | 5 mg | 600 |
| 2024-08-19 | HY-A0173 | 普罗加比 | 10 mM * 1 mLin DMSO | 660 |
