Treatment of Alzheimer’s disease.
Lazabemide Hydrochloride is a reversible and selective inhibitor of MAO-A and MAO-B, both of which oxidatively deaminate neurotransmitter and xenobiotic amines.
ChEBI: Lazabemide hydrochloride is a pyridinecarboxamide.
Tempium (Hoffmann-LaRoche).
Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC 50 values are 0.03 and > 100 μ M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC 50 values are 86, 123 and > 500 μ M for noradrenalin, serotonin and dopamine uptake respectively).
