Physical properties
Bromochlorophene solubility (g/L) in different solvents is as follows: water less than 0.01, 95% ethanol 0.5, propanol 0.7, isopropanol 0.4, propylene glycol 2.5, paraffin oil 0.05.
Uses
Bromochlorophene is used as a microbicide in cosmetics, e.g.,
deodorants, mouthwashes, and toothpastes.
Preparation
Bromochlorophene is produced by bromination of 2,2'-methylenebis(4-chlorophenol) in glacial acetic acid in the cold.
Toxicity evaluation
LD50 (oral, rat)
3700 mg/kg, LD50 (oral, mouse) 1550 mg/kg,
LD50 (dermal, rat) > 10000 mg/kg. Bromochlorophene does not irritate the skin and there
is no evidence of sensitization.
