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How to synthesize Revefenacin?

Dec 22,2023

Overview

Revefenacin is a new M3 muscarinic receptor antagonist, which could prevent acetylcholine from binding with the muscarinic receptor, making bronchodilation and relieving COPD symptoms. Revefenacin has a rapid onset of action, and the curative effect is to maintain a long time[1]. The chemical name for revefenacin is 1-(2-{4-[(4-carbamoylpiperidin-1-yl)methyl]-N-methylbenzamido}ethyl)piperidin-4-yl N- ({1,1' - biphenyl}- 2-yl)carbamate. The molecular weight is 597.76, and the molecular formula is C35H43N5O4.

Developed by Theravance Biopharma and Mylan, revefenacin is a long-acting muscarinic antagonist approved by the USFDA in 2018 for treating chronic obstructive pulmonary disease (COPD). Administered as an inhaled solution, the drug was first licensed to GSK from Theravance in 2004. However, the developing rights were returned to Theravance in 2009 due to incompatibility with GSK’s proprietary inhaler device. Revefenacin binds competitively and reversibly to the muscarinic M3 receptors in the airway smooth muscle, which inhibits bronchoconstriction and increases bronchodilation.

Synthesize method

Article illustration

Three patent applications have been filed by Theravance describing the synthesis and solid form considerations with respect to revefenacin[2]. The approach to the drug's construction essentially involves a linear sequence, which begins with heating piperidine 133 and isocyanate 134 together (neat) to 70 °C. Subsequent treatment with acid, transfer hydrogenation, and pH adjustment (pH ∼12) ultimately furnished carbamate 135 in 99% yield over the four-step sequence. Next, reductive amination with glycine derivative 136, followed by hydrogenolytic removal of the Cbz group and recrystallization in isopropyl alcohol, produced 137 in 96% yield over the three steps. Amide bond formation with acid 138, pH adjustment, and a reductive amination reaction with isonipecotamide 140 completed the assembly of the molecule. Aqueous base workup and subjection to isopropyl alcohol gave rise to revefenacin in 88% yield from aldehyde 139.

References

[1] Fuyuan Li, Junyi Yang. “Revefenacin for the treatment of chronic obstructive pulmonary disease.” Expert Review of Clinical Pharmacology 12 4 (2019): 293–298.

[2] Andrew C. Flick. “Synthetic Approaches to New Drugs Approved during 2018.” Journal of Medicinal Chemistry 63 19 (2020): 10652–10704.

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864750-70-9 RevefenacinSynthesize methodnew M3 muscarinic receptor antagonistCOPD Revefenacin
864750-70-9

Lastest Price from Revefenacin manufacturers

Revefenacin
864750-70-9 Revefenacin
US $75.00-750.00/kg2024-08-27
CAS:
864750-70-9
Min. Order:
10kg
Purity:
0.99
Supply Ability:
20tons
Revefenacin
864750-70-9 Revefenacin
US $0.00/g2024-02-06
CAS:
864750-70-9
Min. Order:
1g
Purity:
99.99%HPLC
Supply Ability:
200kg