Alanine Racemase,中文名为丙氨酸消旋酶,催化L-丙氨酸与D-丙氨酸之间相互转化。本产品为大肠杆菌表达的丙氨酸消旋酶,并经简单纯化获得的可以确保达到一定酶活力的粗酶液。
由于本产品需新鲜制备,确认订购后约6个工作日才可以发货。个别情况首次制备出现问题,发货时间会顺延。
本产品可以提供十公斤、百公斤乃至吨级的粗酶液,如有需求请联系康朗。
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. This enzyme participates in alanine and aspartatemetabolism and D-alanine metabolism. It employs one cofactor, pyridoxal phosphate. At least two compounds, 3-Fluoro-D-alanine and D-Cycloserine are known to inhibit this enzyme.The D-alanine produced by alanine racemase is used for peptidoglycan biosynthesis. Peptidoglycan is found in the cell walls of all bacteria, including many which are harmful to humans. The enzyme is absent in higher eukaryotes but found everywhere in prokaryotes, making alanine racemase a great target for antimicrobial drug development.Alanine racemase can be found in some invertebrates.Bacteria can have one (alr gene) or two alanine racemase genes. Bacterial species with two genes for alanine racemase have one that is continually expressed and one that is inducible, which makes it difficult to target both genes for drug studies. However, knockout studies have shown that without the alr gene being expressed, the bacteria would need an external source of D-alanine in order to survive. Therefore, the alr gene is a feasible target for antimicrobial drugs. This product with the indicated enzyme activity was briefly purified from engineered E.coli. 产品详细信息见下表:
▼
▲
About this product
Name
Alanine Racemase (Crude Enzyme);丙氨酸消旋酶(粗酶液)
Application
催化L-丙氨酸与D-丙氨酸之间相互转化
Appearance
Clear to translucent yellow solution
Enzyme activity
Undetermined
About this enzyme
Name
Alanine Racemase;丙氨酸消旋酶
CAS Number
9024-06-0
EC Number
5.1.1.1
Enzymatic Reaction
L-alanine = D-alanine
Synonyms
L-alanine racemase
Systematic name
alanine racemase
Cofactor(s)
pyridoxal 5'-phosphate
Application
drug development; pharmacology; medicine; pharmacology