盐酸阿比多尔|T0104|TargetMol

Umifenovir hydrochloride
131707-23-8

￥996 25瓶起订

￥528 1瓶起订

￥3355 100瓶起订

￥528 10瓶起订

￥1927 50瓶起订

上海更新日期：2024-09-23

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产品详情:

中文名称：: 盐酸阿比多尔

英文名称：: Umifenovir hydrochloride

CAS号：: 131707-23-8

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.88%

产品类别：: 抑制剂

货号：: T0104

Product Introduction

Bioactivity

名称	Umifenovir hydrochloride
描述	Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.
体外活性	Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. [1] Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). [2] Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. [3] Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. [4] Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively. [5]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : 21 mg/mL (40.9 mM) DMSO : 45 mg/mL (87.57 mM) H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字	SARS coronavirus \| inflammatory \| fusion \| Umifenovir hydrochloride \| SARS-CoV \| Arbidol Hydrochloride \| Inhibitor \| enveloped \| oral \| virus \| inhibit \| Influenza Virus \| Umifenovir Hydrochloride \| Umifenovir
相关产品	Crystal Violet \| Salcomine \| β-Cyclodextrin \| Hydroxychloroquine \| Nitazoxanide \| Curcumin \| α-Vitamin E \| Acetylcysteine \| Naringenin \| Rifampicin
相关库	抑制剂库 \| 经典已知活性库 \| 已知活性化合物库 \| 抗感染化合物库 \| 抗衰老化合物库 \| 上市药物库 \| 抗COVID-19化合物库 \| 抗病毒库 \| 口服活性化合物库 \| 药物功能重定位化合物库

盐酸阿比朵尔|||Arbidol hydrochloride|||Arbidol HCl|||盐酸阿比多尔|TargetMol

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子