苯佐卡因|T0924

Benzocaine
94-09-7

￥280.00 1瓶起订

￥358.00 1瓶起订

￥247.00 500瓶起订

￥115.00 100瓶起订

上海更新日期：2024-09-14

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产品详情:

中文名称：: 苯佐卡因

英文名称：: Benzocaine

CAS号：: 94-09-7

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.97%

产品类别：: 抑制剂

货号：: T0924

Product Introduction

Bioactivity

名称	Benzocaine
描述	Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
体外活性	Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent manner with IC50 of 0.8 mM in HEK293T cells. Benzocaine (1 mM) blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine (1 mM) blocks about 55% of wild-type μ1 currents, but about 80% of μ1-I1575A mutant current. [1] Benzocaine results in a biphasic (protective/inductive) concentration-dependent hemolytic effect upon rat erythrocytes, with an effective Benzocaine:lipid molar ratio in the membrane for protection (RePROT), onset of hemolysis (ReSAT) and 100% membrane solubilization (ReSOL) of 1.0:1, 1.1:1 and 1.3:1, respectively. [2] Benzocaine and 4-hydroxybenzoate interact with the open and inactivated channels during repetitive pulses, but during the interpulse the complex dissociates too fast to accumulate sufficient use-dependent block of Na+ currents. [3] Benzocaine (500 μM) reduces the peak and steady-state currents and increases the amplitude of the inactivating component from 21.7% to 30.2% (n=7, P<0.05), so that benzocaine-induced block at the end of pulses to +60 mV averaged 30.9% (n=7). Benzocaine (500 μM) significantly accelerates the initial phase of deactivation (τf=27.2±2.6 ms, n=7, P<0.01), but does not modify the slow phase of tail current decline. Benzocaine binds with high affinity to an intracellular binding site to produce 'agonist' effects and to a low affinity subsite, which is also located in the inner mouth, to produce the blocking effects. Benzocaine and extracellular K(+) interact to modify the voltage-dependence of channel opening. [4]
体内活性	Benzocaine is absorbed rapidly and similarly through both viable and nonviable skin of the hairless guinea pig, the absorption of the two acidic compounds, benzoic acid and PABA, is greater through nonviable skin. [5]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 50 mg/mL (302.68 mM) Ethanol : 31 mg/mL (187.7 mM)
关键字	Na channels \| 34584 \| Na+ channels \| Inhibitor \| inhibit \| Sodium Channel \| Benzocaine
相关产品	Lidocaine hydrochloride \| Lidocaine \| Valproic Acid \| Mebeverine hydrochloride \| Nefopam hydrochloride \| Amitriptyline hydrochloride \| L-Aspartic aicd sodium \| Riluzole \| Cholesterol \| Phenytoin sodium
相关库	抗癌上市药物库 \| 经典已知活性库 \| 已知活性化合物库 \| 离子通道库 \| NO PAINS 化合物库 \| 膜蛋白靶向化合物库 \| 疼痛相关化合物库 \| 药物功能重定位化合物库 \| 抗癌临床化合物库 \| 抗癌药物库

苯唑卡因|||苯佐卡因

上海陶术生物科技有限公司为美国Target Molecule Corp. ( Target Mol ) 在上海建立的全资子公司。我们与美国波士顿、德国慕尼黑的同事一起，为北美、欧洲和亚洲从事药物研发和生物学研究的科学家提供优质的产品和专业的服务。公司下设筛选事业部，化学事业部，生物事业部和新材料部。从虚拟筛选到实体化合物分子供应；从商业化产品销售到个性化定制合成；从对明确靶点的分子筛选到对明确分子的多靶点筛选，从高通量筛选到化学结构优化，我们都可以满足您的科研用品及技术服务的需求。经过在中国市场五年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛

成立日期	(12年)
注册资本	566.2651万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,试剂,定制,服务
主营行业	化学试剂,生物活性小分子