Chinese name: Group bolone cyclohexyl methyl carbonate
English name: Trenbolone Hexahydrobenzyl Carbonate
CAS: 23454-33-3
EINECS: 245-669-1
Chemical formula: C26H34O4
Molecular weight: 410.55
InChI: InChI=1/C26H34O4/c1-26-14-13-21-20-10-8-19(27)15-18(20)7-9-22(21)23(26)11-12-24(26)30-25(28)29-16-17-5-3-2-4-6-17/h13-1 5,17,22-24 h, 2-12 H2, h3
Density: 1.17± 0.1g /cm3(Predicted)
Melting point: 90-95°
Boiling point: 607.9±55.0 °C(Predicted)
Specific rotation: D20 +41.6° (c = 0.5 in ethanol)
Flash point: 261.7°C
Vapor pressure: 1.01E-14mmHg at 25°C
Refractive index: 1.572
intro
Trenbolone (TRE) is a widely used steroid protein assimilation hormone, which is a chemically synthesized derivative of the human male hormone testosterone similar in structure and activity. It can promote protein synthesis, increase appetite, increase muscle, promote calcium and phosphorus in bone tissue, and can be used clinically to treat severe nutritional deficiencies and osteoporosis and other diseases, but it is also the most frequently used sports stimulants. Trenbolone cyclohexyl methyl carbonate can be used as the synthesis intermediate of Trenbolone.
preparation
Trenbolone cyclohexyl methyl carbonate is prepared as follows: 3G17/3-hydroxy-estradiol-4,9, 11-triene-3-one is dissolved in pyridine at 15℃ and 0℃ under stirring and nitrogen atmosphere. Keep the temperature between 0 and 10 degrees Celsius. Slowly add 50ml hexahydrobenzyl chloroformate, then warm the whole mixture to ambient temperature, stir for 2 hours, and then cool to 0 ° C. Add the triethylamine, stir for 30 minutes to raise the temperature to ambient temperature, and pour the reaction mixture into the water/ice mixture. It is extracted with methylene chloride, and the organic phase is washed with water to neutral, dried with sodium sulfate, and vacuum evaporated to dry. The residue was chromatographically separated on silica gel, eluted with 4:1 mixture of benzene/ethyl acetate, and recrystallized from isopropyl ether/hexane mixture. It was separated by chromatography on silica gel again, eluted with benzene/ethyl acetate ethyl acetate mixture, and finally recrystallized from cyclohexane and petroleum ether to obtain 1.60g group boloncyclohexyl methyl carbonate. The product appears in prismatic form soluble in ethanol, ether, benzene, acetone, and chloroform, but insoluble in water, dilute acid, and alkaline water solutions.
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