Product Name:	Maraviroc
Synonyms:	Maraviroc;Maraviroc(UK427857);4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide;UK-427857; CELSENTRI;CS-49;maroviroc;4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide;Maraviroc(Selzentry)
CAS:	376348-65-1
MF:	C29H41F2N5O
MW:	513.68
EINECS:	609-456-0
Product Categories:	UK-427857, Celsentri;Other APIs;Anti-AIDS;Chiral Reagents;Inhibitors;Pfizer compounds;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	376348-65-1.mol

Melting point	79-81°C
density	1.29±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: >30mg/mL
pka	7.3(at 25℃)
form	white powder
color	White
optical activity	[α]-15/D
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI	InChI=1/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/s3
InChIKey	GSNHKUDZZFZSJB-RWJISDSDNA-N
SMILES	C(N1[C@@H]2CC[C@H]1C[C@H](N1C(=NN=C1C(C)C)C)C2)C[C@@H](C1C=CC=CC=1)NC(C1CCC(F)(F)CC1)=O \|&1:2,5,7,19,r\|
CAS DataBase Reference	376348-65-1(CAS DataBase Reference)

Chemical Properties	Brown Solid
Originator	Pfizer (US)
Uses	Maraviroc is a potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.
Uses	Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral
Uses	Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively

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