5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Basic information

Product Name:

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

Synonyms:

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL;RITA;p53 Activator III;RITA (NSC 652287);(5,5'-(furan-2,5-diyl)bis(thiophene-5,2-diyl))diMethanol;RITA, >99%;2-Thiophenemethanol, 5,5'-(2,5-furandiyl)bis-;5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol RITA (NSC 652287)

CAS:

MF:

C14H12O3S2

MW:

292.37328

EINECS:

 

Product Categories:

Inhibitor;Inhibitors

Mol File:

213261-59-7.mol

 

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Chemical Properties

storage temp. 

Store at -20°C

form 

Crystalline solid

Sensitive 

Light Sensitive

 

Safety Information

HS Code 

29321900

MSDS Information

 

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Usage And Synthesis

Uses

NSC 652287, a DNA damaging agent. It induces p53 tumor suppressor protein.

Biological Activity

Anti-tumor agent that binds wild-type p53 (K d = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo .