| Lovastatin Basic information |
| a cholesterol lowering agent General description Structure of statin compound Active Mechanism Medicinal Value Biosynthesis Uses Metabolism Precautions Adverse reaction Chemical property Uses Production method |
| Product Name: |
Lovastatin |
| Synonyms: |
SiMvastatin EP IMpurity E;8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphth;Mevinolin, 6-alpha-Methylcompactin;Mevinolin, Monacolin K, L 154803, MB 530B, MSD 803;Lovastatin (Mevacor);(2S)-2-methyl-butanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester;Lovastatin for peak identification;[8-[2-(4-hydroxy-6-oxooxan-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate |
| CAS: |
75330-75-5 |
| MF: |
C24H36O5 |
| MW: |
404.54 |
| EINECS: |
1308068-626-2 |
| Product Categories: |
chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Isotopically Labeled Pharmaceutical Reference Standard;RYTHYMOL;antibiotic;Cardiovascular APIs;Inhibitors;Antibiotics;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's;HMG-CoA reductase;Chiral Reagents;Heterocycles;Inhibitor |
| Mol File: |
75330-75-5.mol |
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| Lovastatin Chemical Properties |
| Melting point |
175°C |
| alpha |
D25 +323° (c = 0.5 g in 100 ml acetonitrile) |
| refractive index |
320 ° (C=0.5, CH3CN) |
| storage temp. |
2-8°C |
| solubility |
ethanol: soluble9.80-10.20mg/mL, clear, colorless to faintly yellow |
| Water Solubility |
0.0004 mg/mL at 25 ºC |
| Merck |
14,5586 |
| CAS DataBase Reference |
75330-75-5(CAS DataBase Reference) |
| EPA Substance Registry System |
Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7, 8,8a-hexahydro-3,7-dimethyl- 8-[2-[(2R,4R)-tetrahydro- 4-hydroxy-6-oxo-2H-pyran- 2-yl]ethyl]-1-naphthalenyl ester, (2S)-(75330-75-5) |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
22-24/25-36/37/39-26 |
| RIDADR |
3077 |
| WGK Germany |
3 |
| RTECS |
EK7907000 |
| HazardClass |
9 |
| PackingGroup |
III |
| Hazardous Substances Data |
75330-75-5(Hazardous Substances Data) |
| Toxicity |
LD50 orally in mice: >1000 mg/kg (Endo) |
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China
