tadalafil

Absorption was rapid after oral administration, and the median time after administration was 2 hours to reach the mean upper observed plasma concentration (Cmax). Bioavailability after oral administration of this product has not been determined. The absorption rate and degree of tadalafil are not affected by food, so this product may be taken with or without food. The timing of administration (morning or evening) had no clinically significant effect on absorptance or extent, and the mean volume of distribution was about 63 liters, indicating that tadalala was not distributed into tissues. At treatment concentration, 94% of tadalafil in plasma is bound to protein. Protein binding was not affected by renal impairment. The mean clearance rate of oral tadalala in healthy subjects was 2.. 5L/hr, with an average half-life of 17.5 hours. Tadalafil is excreted mainly as inactive metabolites, mainly from feces (about 61% of the dose) and to a lesser extent from urine (about 36% of the dose)