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Application
Dexamethasone (Dexamethasone, DXMS for short) is a synthetic corticosteroid, can be used to treat a variety of symptoms, include rheumatic diseases (English: rheumatology), some skin diseases, severe allergies, asthma, chronic obstructive pulmonary disease (copd), membranous, laryngitis, cerebral edema (English: cerebral edema), may also be used for patients with tuberculosis (TB) in combination with antibiotics.For adrenocortical insufficiency (English: adrenocortical insufficiency) of the patients and served with salt cortical hormone drugs, such as the rich can ingot (English: fludrocortisone) and so on.Use of dexamethasone in premature infants improves prognosis.It usually starts to work within a day and lasts about three days.Long-term use of dexamethasone can lead to candidiasis, bone loss, cataracts, bruising, or muscle
Preparation method
A new method of dexamethasone 21 - hydroxyl content of the production process, intermediate 21 - acetate as the substrate, with a moderate amount of methanol containing 0 ~ 10% chloroform as solvent to half dissolved substrate for hydrolysis reaction with alkali as the catalyst, and reaction with acetic acid neutralization after completely, condensed the reaction liquid pressure to moderate volume, cooling, filtering, flush filter cake, dry 21 - hydroxyl content.The process can shorten the production cycle, improve the quality and yield of 21-hydroxyl compounds, and reduce the content of impurities in 21-hydroxyl compounds.
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China
