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Urotensin II (114-124), human TFA

Urotensin II (114-124), human TFA

英文名称:Urotensin II (114-124), human TFA
CAS号:
分子式:C??H??F?N??O??S?
分子量:0
EINECS号:
Mol文件:Mol File
Urotensin II (114-124), human TFA 结构式

Urotensin II (114-124), human TFA 性质

形态 固体
颜色 白色至米白色

Urotensin II (114-124), human TFA 用途与合成方法

Urotensin II (114-124), human TFA 是一个含 11 个氨基酸的残基肽,是孤儿受体 GPR14 激动剂,是一有效血管收缩剂。

GPR14

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC 50 =0:62±0.17 nM, n=6).

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.

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