YK-4-279
1037184-44-3 Basic informationMore
- Product Name:YK-4-279
- Synonyms: YK-4-279 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one YK-4-279 YK-4-279;YK 4-279 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one CS-1785 2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]- YK-4-279 USP/EP/BP
- CAS:1037184-44-3
- MF:C17H13Cl2NO4
- MW:366.2
- EINECS:
- Mol File:1037184-44-3.mol
-
USE
An oncogenic fusion protein found in Ewing's sarcoma, a family of undifferentiated tumors which occur throughout the body. The binding of ES-FLI1 to RNA helicase A (RHA) promotes its oncogenic function. Inhibits protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing's sarcoma tumor cell lines with IC50 values ranging from 0.5 to 2 μM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing's sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:YK 4-279;4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-Methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
CAS:1037184-44-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15848)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:YK 4-279
CAS:1037184-44-3
Remarks:C14700 More... - CB Index:61
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:YK4-279
CAS:1037184-44-3
Purity:>98%,BR Package:10MG;50MG;200MG Remarks:MB4134 - CB Index:58
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- Company Name:Wuhan TCASChem Technology Co., Ltd.
- Tel:027-027-86697669 13986148687
- Products Intro:CAS:1037184-44-3
Purity:98% HPLC Package:5g,10g,25g,100g,1kg More... - CB Index:55
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:YK-4-279
CAS:1037184-44-3
Purity:>=98% Package:100mg/RMB 3217.90;10mg/RMB 602.90;50mg/RMB 2114.90 More... - CB Index:65
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- Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
- Tel:020-39119399 18927568969
- Products Intro:Product Name:YK-4-279
CAS:1037184-44-3
Purity:99.0% Package:1G; 25G; 1KG; 25KG More... - CB Index:55
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