Saroglitazar
495399-09-2 Basic informationMore
- Product Name:Saroglitazar
- Synonyms: Saroglitazar Benzenepropanoic acid, α-ethoxy-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]-, (αS)- (S)-2-Ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoic acid
- CAS:495399-09-2
- MF:C25H29NO4S
- MW:439.57
- EINECS:
- Mol File:495399-09-2.mol
-
USE
Saroglitazar (also known as ZYH1) was approved for use by the Drug Controller General of India for the treatment of diabetic dyslipidemia and hypertriglyceridemia that is not controlled by statin therapy. Saroglitazar is the first approved agent with dual PPAR agonist activity, with EC<sub>50s</sub> of 0.00065 and 3 nM, respectively, for the α- and γ-PPAR isoforms in HepG2 cells. The medicinal chemistry program has not been described in the scientific literature, but numerous substituents on the pyrrole ring are described in the saroglitazar patent. These substituted pyrroles were synthesized via ethanolamine condensation with substituted diketones and subsequent activation of the hydroxyethylpyrrole for phenolic etherification with (S)-2- ethoxy-3-(4-hydroxyphenyl)propanoic acid. The efficacy of saroglitazar was evaluated in db/db mice (genetically diabetic animals that lack the leptin receptor), wherein it produced a 17–55% reduction in serum triglycerides (TGs) after 12 days of administration of saroglitazar (0.01–3 mg/kg).
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- Company Name:Beijing Jingzi Pharmaceutical Technology Co., Ltd.
- Tel: 15011485209
- Products Intro:Product Name:Saroglitazar
CAS:495399-09-2
Purity:98% HPLC Package:1G;1KG - CB Index:58
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- Company Name:Nantong Hi-Future Biotechnology Co., Ltd
- Tel: 18051384581
- Products Intro:Product Name:Saroglitazar
CAS:495399-09-2
Purity:98% HPLC Package:10mg，500mg，1g，5g，10g，more - CB Index:58
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- Company Name:Suzhou Haiben Pharmaceutical Co., Ltd
- Tel:14760821013 14760821013
- Products Intro:Product Name:Saroglitazar
CAS:495399-09-2
Purity:98% HPLC Package:10g;100g;1kg;10kg - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Saroglitazar
CAS:495399-09-2
Package:50Mg,5Mg More... - CB Index:76
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- Company Name:Dtchem Laboratories,（Gan Su）Co.,Ltd.
- Tel: 18993966060
- Products Intro:Product Name:Saroglitazar
CAS:495399-09-2
Purity:95% HPLC Package:5KG;1KG;100G;50G;25G;10G - CB Index:61
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- Company Name:Artis Biotech Co. Ltd.
- Tel:19138486554 18582380095
- Products Intro:Product Name:Saroglitazar
CAS:495399-09-2
Purity:99% HPLC Package:5mg 20mg 50mg 100mg 200mg 1g More... - CB Index:58
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- Company Name:Amadis Chemical Company Limited
- Tel:571-89925085
- Products Intro:Product Name:Saroglitazar
CAS:495399-09-2
Purity:0.97 Package:mgs,gs,kgs Remarks:A913988 - CB Index:58
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