BMS-754807
1001350-96-4 Basic informationMore
- Product Name:BMS-754807
- Synonyms: (2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)aMino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoropyridin-3-yl)-2-Methylpyrrolidine-2-carboxaMide (S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)aMino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-Methylpyrrolidine-2-carboxaMide BMS-754807 (2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide (2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide BMS 754807 BMS 754807 (2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide (S)-1-(1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-2-methylpyrrolidin-2-yl)-2-((6-fluoropyridin-3-yl)amino)ethanone
- CAS:1001350-96-4
- MF:C23H24FN9O
- MW:461.49
- EINECS:
- Mol File:1001350-96-4.mol
-
USE
BMS 754807 is a reversible, orally bioavailable dual inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases (IC50s = 1.8 and 1.7 nM, respectively). It has minimal effect against an array of other tyrosine and serine/threonine kinases. BMS 754807 inhibits cell proliferation or induces apoptosis in a variety of cancer cells in vitro. It inhibits the growth of tumor xenografts in mice and this effect is often enhanced by combination therapy with other chemotherapeutics. Predictive biomarkers, including elevated IGF-1R expression, for effectiveness of BMS 754807 have been delineated.[Cayman Chemical]
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:BMS 754807
CAS:1001350-96-4
Remarks:C14683 More... - CB Index:61
- Related Information:Catalog(6008)
- Company Name:Nanjing Chemlin Chemical Co., Ltd
- Tel:025-83697070
- Products Intro:Product Name:(2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide
CAS:1001350-96-4
Purity:98% Package:5KG; 1KG More... - CB Index:64
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- Company Name:Shanghai AmasPharm Co., Ltd.
- Tel:021-54540637 18621091017
- Products Intro:Product Name:BMS-754807
CAS:1001350-96-4
Purity:97% Package:1g;5g;10g - CB Index:62
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:BMS-754807
CAS:1001350-96-4
Purity:>98% Package:50MG Remarks:4600 More... - CB Index:58
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- Company Name:Shanghai Topbiochem Technology Co., Ltd
- Tel:021-58170097
- Products Intro:Product Name:BMS-754807
CAS:1001350-96-4
Purity:98% Package:25g;100g;500g;1kg - CB Index:58
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