A77 1726
163451-81-8 Basic informationMore
- Product Name:A77 1726
- Synonyms: A77 1726 (Teriflunomide) A 1726 Flucyamide HMR 1726 (Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide LeflunoMide EP IMpurity B Leflunomide Impurity 2(Leflunomide EP Impurity B) A-771726;A 771726;A771726
- CAS:163451-81-8
- MF:C12H9F3N2O2
- MW:270.21
- EINECS:642-273-4
- Mol File:163451-81-8.mol
-
USE
A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]
Lastest Price from A77 1726 manufacturers
- Teriflunomide
-
- US $0.00-0.00/Kg/Drum
- CAS:163451-81-8
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1000KGS
- 2024-09-18
- A77 1726
-
- US $3.00 /kg
- CAS:163451-81-8
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10000
- 2024-09-03
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- Company Name:Jiangxi ravel Biotechnology Co.,Ltd
- Tel:400-880-2824 18107960669
- Products Intro:Product Name:teriflunomide
CAS:163451-81-8
Purity:99 Package:1kg/ - CB Index:58
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- Tel:17362916295; 17362916295
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Purity:99% HPLC Package:5KG;1KG - CB Index:58
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CAS:163451-81-8
Package:1kg/ - CB Index:55
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- Tel:010-82848833 400-666-7788
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Package:100Mg,10Mg,1g,25Mg More... - CB Index:76
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- Tel:021-67121386
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Purity:98.0% GC Package:100MG,1G More... - CB Index:81
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CAS:163451-81-8
Purity:对照品 Package:10mg~500mg Remarks:AC000163000 - CB Index:59
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- Company Name:Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd
- Tel: 18901358086
- Products Intro:Product Name:TeriflunoMide
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