Rosiglitazone maleate

• Product Name:Rosiglitazone maleate
• Synonyms: 5-((4-[2-(METHYL-2-PYRIDINYLAMINO)-ETHOXY]-PHENYL)-METHYLENE)-2,4-THIAZOLIDINEDIONE 5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate ROSIGLITAZONE MALEATE RosiglitazoneTartrate Avandi BRL-49653c RSIGLITAZONEMALEATE 5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione Maleate
• CAS:155141-29-0
• MF:C22H23N3O7S
• MW:473.5
• EINECS:642-163-6
• Mol File:155141-29-0.mol
• 

Rosiglitazone maleate, belongs to a novel class of thiazolidine diones launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), a disease characterized by a pancreatic β-cell defect and insulin resistance in the liver and peripheral tissues. The racemic base can be obtained by KnSvenagel condensation between 2, 4-thiazolidinedione and the corresponding 4-substituted benzaldehyde (itself prepared in 2 steps from 2-chloropyridine), followed by reduction of the benzylidene. Rosiglitazone was shown to be a potent agonist of peroxisome proliferator activated receptor-gamma (PPARgamma), a nuclear receptor involved in the differentiation of adipose tissue, without activating liver PPAR-alpha receptors. This activation of PPAR-gamma could mediate the down-regulation of leptin gene expression. In animal models, Rosiglitazone has been shown to normalize glucose metabolism and reduce the exogenous dose of insulin needed to achieve glycemic control. In patients with Type II diabetes, daily doses (4 or 8 mg) of Rosiglitazone significantly improved blood sugar control without affecting cardiac structure or function.

• Rosiglitazone maleate
• 
• US $0.00-0.00/kg
• CAS:155141-29-0
• Min. Order: 1kg
• Purity: 98.0%
• Supply Ability: 1kg/month
• 2024-09-18

• Rosiglitazone maleate
• 
• US $80.00 /KG
• CAS:155141-29-0
• Min. Order: 1KG
• Purity: 99.9%
• Supply Ability: 500MT/month
• 2023-03-27

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Rosiglitazone Maleate
  CAS:155141-29-0
  Package:250Mg,25Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Nanjing Chemlin Chemical Co., Ltd
• Tel:025-83697070
• Products Intro:Product Name:5-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione maleate
  CAS:155141-29-0
  Purity:98% Package:5KG; 1KG More...
• CB Index:64
• Related Information:Catalog(19116)

• Company Name:Hunan Hui Bai Shi Biotechnology Co., Ltd.
• Tel:0731-85526065 13308475853
• Products Intro:Product Name:rosiglitazone maleate
  CAS:155141-29-0
  Purity:99% Package:100mg;25mg;500mg
• CB Index:62
• Related Information:Catalog(4554)

• Company Name:Wuhan Fortuna Chemical Co., Ltd
• Tel:027-59207852 13308628970
• Products Intro:Product Name:Rosiglitazone Maleate
  CAS:155141-29-0
  Purity:99% Package:1kg More...
• CB Index:58
• Related Information:Catalog(2878)