1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE suppliers

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

CAS:: 28289-54-5

MF:: C12H15N

MW:: 173.25

SecurityInformation

Symbol(GHS) ：: GHS08,GHS06

Signal word ：: Danger

Hazard statements ：: H370-H301

Precautionary statements ：: P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501

Hazard Codes ：: T

Risk Statements ：: 25-39/23/24/25

Safety Statements ：: 45

RIDADR ：: UN 2811 6.1/PG 2

WGK Germany ：: 3

RTECS ：: UT8358900

HazardClass ：: 6.1(b)

PackingGroup ：: III

Toxicity：: Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

Use：: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

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