Clinical Use
IgG2 monoclonal antibody:Treatment of hypercholesterolaemia, mixed
dyslipidaemia and homozygous familial
hypercholesterolaemia
Drug interactions
Potentially hazardous interactions with other drugs
Antipsychotics: avoid with clozapine - increased risk
of agranulocytosis.
Vaccines: avoid concomitant use with live vaccines.
Metabolism
Evolocumab is composed of amino acids and
carbohydrates as native immunoglobulin and is unlikely
to be eliminated via hepatic metabolic mechanisms.
Its metabolism and elimination are expected to follow
the immunoglobulin clearance pathways, resulting in
degradation to small peptides and individual amino acids.
