CALMODULIN

Uses

Activates cyclic phosphodiesterase

Uses

This is the protein activator required for the Ca²⁺ dependent activation of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520.

Definition

A protein, consistingof 148 amino-acid residues, that actsas a receptor for calcium ions inmany calcium-regulated processes inboth animal and plant cells. Calmodulinmediates reactions catalysed bymany enzymes.

Biochem/physiol Actions

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.