Description
N-
(4-
acetamidophenyl)-
indomethacin amide (N-
4-
AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-
2. N-
4-
AIA inhibits human recombinant and ovine COX-
2 with IC
50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-
1 and 80 times less potent as an inhibitor of ovine COX-
1 than ovine COX-
2.
Chemical Properties
Pale Yellow Solid
Uses
An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively
Definition
ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.
References
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.
