Groenlandicine

Chemical Properties

Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Used for content determination/identification/pharmacological experiments, etc.

Health effects

Groenlandicine has an anti-inflammatory, analgesic, cooling, antihypertensive, anticancer effect.

Biological Activity

Groenlandicine is a protoberberine alkaloid isolated from Coptis chinensis. It has moderate inhibitory effect on human recombinant aldose reductase (HRAR) with IC50 value of 154.2 μM. And Groenlandicine can induces topoisomerase I (topoisomerase I)-mediated DNA cleavage.

target

Topoisomerase I