Description
Obtained from Desmodium pulchellum Benth ex Baker, and also from Phalaris
tuberosa L., this indole alkaloid is best crystallized from Et20-light petroleum
when it yields colourless rectangular plates. It is optically inactive and the ultraviolet
spectrum has absorption maxima at 224, 277 and 296 mil. It forms a
crystalline picrate as orange-yellow needles, m.p. 176-7°C and the methiodide,
m.p. 181-2°C.
Chemical Properties
off-white to slightly yellow crystalline powder
Uses
Hallucinogen; non-selective serotonin receptor agonist
Uses
5-Methoxy-N,N-dimethyltryptamine is a tryptamine derivative and a full potent agonist used in the study of mammalian hormones to stimukate cAMP formation by colliculi neurons and mediate serotoninergic receptors. It is a natural hallucinogen component of Ayahuasca, an Amazonian beverage and is currently being made as a designer drug.
Definition
ChEBI: A tryptamine alkaloid that is N,N-dimethyltryptamine substituted by a methoxy group at position 5.
References
Culvenor, Brown, Smith., Austral. J. Chern., 17, 1301 (1964)
Ghosal, Mukherjee., Chern. Ind., 793 (1965)
Ghosal, Mukherjee., J. Org. Chern., 31, 2284 (1966)
