EveroliMus-d4
- Product NameEveroliMus-d4
- CAS1338452-54-2
- CBNumberCB32714520
- MFC53H79D4NO14
- MW962.249067112
- MOL File1338452-54-2.mol
Chemical Properties
storage temp. | Store at 4°C |
solubility | Chloroform: Soluble,Methanol: Soluble |
form | A solid |
color | White to off-white |
Stability | Hygroscopic |
EveroliMus-d4 Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
Sigma-Aldrich E-070 | 1mL | $586 | Everolimus-D4 solution 100?μg/mLinacetonitrile,ampuleof1?mL,certifiedreferencematerial,Cerilli |
Buy |
Cayman Chemical 22559 | 500μg | $145 | Everolimus-d4 ≥99% deuterated forms (d1-d4); ≤1% d0 |
Buy |
Cayman Chemical 22559 | 1mg | $262 | Everolimus-d4 ≥99% deuterated forms (d1-d4); ≤1% d0 |
Buy |
TRC E945402 | 10mg | $1695 | Everolimus-d4(~90%) |
Buy |
IsoSciences 14001 | 1mg | $190 | Everolimus-[d4] ≥98% |
Buy |
EveroliMus-d4 Chemical Properties,Usage,Production
Description
Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation.Uses
Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation.General Description
A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress? and Certican for use in organ transplantation and Afinitor? for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.Preparation Products And Raw materials
EveroliMus-d4 Suppliers
Global(43)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 | |
+1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 | |
021-50135380 | shchemsky@sina.com | China | 32344 | 50 | |
400-400-6206333 18521732826 |
market@aladdin-e.com | China | 25009 | 65 | |
020-81960175 | min.he@cato-chem.com | China | 1958 | 55 | |
19138486554 18582380095 |
sales@artisbio.com | China | 2765 | 58 | |
025-84622273 17361806303 |
3004208264@qq.com | China | 3022 | 58 | |
+86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 | |
0551-66336380 18956014586 |
983438788@qq.com | China | 2116 | 58 | |
020-36607679 17825480238 |
3008233717@qq.com | China | 9919 | 12 |
1338452-54-2, EveroliMus-d4Related Search
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- USDOYNAPNXMXOE-SPSCNLKESA-N
- 23,27-Epoxy(7E,15E,17E,19E)-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexam...
- Rapamycin, 32-O-demethyl-
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