生物活性 靶点 体外研究 体内研究 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 试剂级价格
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ChemicalBook  CAS数据库列表  1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE

1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE

生物活性 靶点 体外研究 体内研究 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 试剂级价格
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE,1125758-85-1,结构式
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
  • CAS号:1125758-85-1
  • 英文名:A 804598
  • 中文名:1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
  • CBNumber:CB82602998
  • 分子式:C19H17N5
  • 分子量:315.37
  • MOL File:1125758-85-1.mol
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE化学性质
  • 沸点 :498.0±47.0 °C(Predicted)
  • 密度 :1.17±0.1 g/cm3(Predicted)
  • 储存条件 :Keep in dark place,Sealed in dry,2-8°C
  • 溶解度 :DMSO: soluble10mg/mL, clear
  • 形态 :powder
  • 酸度系数(pKa) :4.52±0.12(Predicted)
  • 颜色 :white to beige
安全信息
  • 危险品标志 :T
  • 危险类别码 :25
  • 安全说明 :45
  • 危险品运输编号 :UN 2811 6.1 / PGIII
  • WGK Germany :3

1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE性质、用途与生产工艺

  • 生物活性 A-804598 是一个 CNS 渗透，竞争性和选择性的 P2X7 受体拮抗剂，作用于小鼠，大鼠和人的 P2X7 受体，IC50s 分别是 9 nM, 10 nM 和 11 nM。
  • 靶点

    IC50: 9 nM (mouse P2X7 receptor), 10 nM (rat P2X7 receptor), 11 nM (human P2X7 receptor)

  • 体外研究

    Pre-incubation with A-804598 (0.1-10 μM; 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity.

    Cell Cytotoxicity Assay

    Cell Line: microglial cell
    Concentration: 0.1, 0.3, 1, 3, 10 μM
    Incubation Time: 1 hour
    Result: Protected against BzATP-induced cytotoxicity in both inactivated and activated microglia.
  • 体内研究

    A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease.

    Animal Model: Adult B6.Cg-Tg (SOD1-G93A) 1Gur/J female mice
    Dosage: 30 mg/kg
    Administration: Intraperitoneal injection; five times a week
    Result: Decreased SQSTM1/p62 expression.
1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE上下游产品信息
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1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 试剂级价格
  • 更新日期：2024/08/19
  • 产品编号：HY-100483
  • 产品名称：A-804598
  • CAS编号：
  • 包装：1 mg
  • 价格：300元
  • 更新日期：2024/08/19
  • 产品编号：HY-100483
  • 产品名称：1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE A-804598
  • CAS编号：1125758-85-1
  • 包装：5mg
  • 价格：550元
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