ChemicalBook CAS数据库列表 ZM323881
ZM323881
- CAS号:193001-14-8
- 英文名:5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL
- 中文名:ZM323881
- CBNumber:CB6811963
- 分子式:C22H18FN3O2
- 分子量:375.4
- MOL File:Mol file
ZM323881化学性质
- 沸点 :543.6±50.0 °C(Predicted)
- 密度 :1.342±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :White to off-white solid.
- 酸度系数(pKa) :9.99±0.23(Predicted)
ZM323881性质、用途与生产工艺
- 生物活性 ZM323881是有效，选择性的 VEGFR2 抑制剂， IC50 值小于2 nM。
-
靶点
VEGFR2
2 nM (IC 50 )
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体外研究
ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC 50 >50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC 50 =8 nM) and VEGFR2 tyrosine phosphorylation. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM.
ZM323881上下游产品信息
上游原料
下游产品
ZM323881生产厂家
- 公司名称：Axon Medchem BV
- 联系电话：--
- 电子邮件：info@axonmedchem.com
- 国家：荷兰
- 产品数：477
- 优势度：30
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