ChemicalBook CAS数据库列表 (R)-比卡鲁胺
(R)-比卡鲁胺
- CAS号:113299-40-4
- 英文名:(R)-Bicalutamide
- 中文名:(R)-比卡鲁胺
- CBNumber:CB6174499
- 分子式:C18H14F4N2O4S
- 分子量:430.37
- MOL File:113299-40-4.mol
(R)-比卡鲁胺化学性质
- 熔点 :178-181°C
- 沸点 :650.3±55.0 °C(Predicted)
- 密度 :1.52±0.1 g/cm3(Predicted)
- 储存条件 :-20°C Freezer
- 溶解度 :Acetone (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- 酸度系数(pKa) :11.49±0.29(Predicted)
- 形态 :Solid
- 颜色 :White to Off-White
- CAS 数据库 :113299-40-4(CAS DataBase Reference)
(R)-比卡鲁胺性质、用途与生产工艺
- 生物活性 (R)-Bicalutamide 是 Bicalutamide (HY-14249) 的 R 型对映体。(R)-Bicalutamide 是一种雄激素受体 (AR) 拮抗剂,具有抗肿瘤活性。(R)-Bicalutamide 广泛用于前列腺癌的研究。
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靶点
AR
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体外研究
Bicalutamide (HY-14249) is available as a racemic mixture. The R isomer (R-bicalutamide) has an ≈30-fold higher binding affinity to the AR than the S isomer.
(R)-bicalutamide (0.02-20 μM) reduces naïve LNCaP cells survival in a dose-dependent.
Cell Proliferation Assay
Cell Line: LNCaP cells, LNCaP-Rbic cells Concentration: 0.02 μM, 0.2 μM, 2 μM, 20 μM Incubation Time: 144 hours Result: Reduced naïve LNCaP cells survival in a dose-dependent, with an IC 50 value of about 7μM; exerted a poor antiproliferative effect on LNCaP-Rbic. -
体内研究
(R)-Bicalutamide (10 mg/kg; i.g.; daily; for 4 days) has antitumor efficacy in VCaP xenografts mice.
Animal Model: CD1 male nude (nu/nu) mice, with VCaP xenografts Dosage: 10 mg/kg Administration: Orally gavage, daily, for 4 consecutive weeks Result: Suppressed tumor growth.
(R)-比卡鲁胺上下游产品信息
上游原料
下游产品
(R)-比卡鲁胺 试剂级价格
- 更新日期:2024/08/19
- 产品编号:HY-108250
- 产品名称:(R)-比卡鲁胺 (R)-Bicalutamide
- CAS编号:113299-40-4
- 包装:5mg
- 价格:900元
- 更新日期:2024/08/19
- 产品编号:HY-108250
- 产品名称:(R)-比卡鲁胺 (R)-Bicalutamide
- CAS编号:113299-40-4
- 包装:10mM * 1mLin DMSO
- 价格:990元
(R)-比卡鲁胺生产厂家
- 公司名称:AXXORA, LLC
- 联系电话:--
- 电子邮件:alexis-ch@alexis-corp.com
- 国家:瑞士
- 产品数:1104
- 优势度:80
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