贝托斯汀
- CAS号:125602-71-3
- 英文名:BEPOTASTINE
- 中文名:贝托斯汀
- CBNumber:CB3102554
- 分子式:C21H25ClN2O3
- 分子量:388.89
- MOL File:125602-71-3.mol
- 熔点 :56 - 58°C
- 沸点 :546.8±50.0 °C(Predicted)
- 密度 :1.26
- 储存条件 :-20°C Freezer, Under inert atmosphere
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 酸度系数(pKa) :4.44±0.10(Predicted)
- 形态 :Solid
- 颜色 :White to Pale Beige
贝托斯汀性质、用途与生产工艺
- 生物活性 Bepotastine是一种非镇静的、选择性histamine 1 (H1) receptor拮抗剂。
-
靶点
Histamine H1 receptor
-
体外研究
Bepotastine possesses additional anti-allergic activity including stabilization of mast cell function, inhibition of eosinophilic infiltration, inhibition of IL-5 production, and inhibition of leukotriene B4 (LTB4) and LTD4 activity.
Bepotastine significantly inhibits antigen-induced stimulation of IL-5 production in human peripheral blood mononuclear cells (PBMCs) at concentrations of 10-100 μM and the effect is enhanced when the PBMCs are pre-incubated with Bepotastine.
Leukotriene B4 increased Ca2+ concentration in cultured neutrophils, which is suppressed by Bepotastine besilate (1-100 μM). Leukotriene B4 increased Ca2+ concentration in cultured dorsal root ganglion neurons, which is also suppressed by Bepotastine besilate (100 μM). -
体内研究
Bepotastine besilate (10 mg/kg) inhibits scratching induced by an intradermal injection of histamine (100 nmol/site), but not serotonin (100 nmol/site).
Bepotastine besilate (1-10 mg/kg, oral) dose-dependently suppresses scratching induced by substance P (100 nmol/site) and leukotriene B4 (0.03 nmol/site). Bepotastine in vivo dose-dependently inhibits the acceleration of histamine-induced vascular permeability and inhibits homologous passive cutaneous anaphylaxis in guinea pig studies.
In mouse models of itching, oral Bepotastine inhibits the frequency and duration of scratching behavior.
- 更新日期:2024/08/19
- 产品编号:HY-I0021
- 产品名称:Bepotastine
- CAS编号:
- 包装:5 mg
- 价格:750元
- 更新日期:2024/08/19
- 产品编号:HY-I0021
- 产品名称:贝托斯汀 Bepotastine
- CAS编号:125602-71-3
- 包装:10mg
- 价格:1200元
- 公司名称:Pharma Affiliates
- 联系电话:--
- 电子邮件:@pharmaffiliates.com
- 国家:印度
- 产品数:6761
- 优势度:58
- 公司名称:Azico Pharmaceuticals Private Limited
- 联系电话:--
- 电子邮件:
- 国家:印度
- 产品数:6
- 优势度:58
- 公司名称:Pharmaffiliates Analytics and Synthetics P. Ltd
- 联系电话:--
- 电子邮件:mktg@pharmaffiliates.com
- 国家:印度
- 产品数:6773
- 优势度:58
- 公司名称:SynZeal Research Pvt Ltd
- 联系电话:--
- 电子邮件:standards@synzeal.com
- 国家:印度
- 产品数:6522
- 优势度:58
- 公司名称:CLEARSYNTH LABS LTD.
- 联系电话:--
- 电子邮件:sales@clearsynth.com
- 国家:印度
- 产品数:6351
- 优势度:58
- 公司名称:Ralington Pharma
- 联系电话:--
- 电子邮件:info@ralingtonpharma.com
- 国家:印度
- 产品数:1350
- 优势度:58
- 公司名称:Anant Pharmaceuticals Pvt Ltd
- 联系电话:--
- 电子邮件:sales@anantlabs.com
- 国家:印度
- 产品数:461
- 优势度:58
- 公司名称:Manus Aktteva
- 联系电话:--
- 电子邮件:info@manusaktteva.in
- 国家:印度
- 产品数:581
- 优势度:34