72459-58-6

Fungicide.

Triazoxide is a pesticide.

Triazoxide is used as a seed dressing for the control of seed-borne diseases in winter and spring barley.

ChEBI: A member of the class of benzotriazines that is 1,2,4-benzotriazine 1-oxide which is substituted by chlorine at position 7 and by a 1H-imidazol-1-yl group at position 3. A fungicide, it is used as a seed treatment for control of seed-bor e Pyrenophora graminea and Pyrenophora teres in barley.

Triazoxide was the subject of an evaluation by the Pesticide Safety Directorate of UK MAFF. The information presented below was obtained from this source (PSD, 1994). The specific use of triazoxide (seed treatment) gives rise to very low residues and therefore the metabolic pathways in plants were not investigated. The compound is rather persistent in soils and sediments but it is likely to be short-lived in water owing to photolysis. Much is known about the absorption, distribution and elimination of the compound in rat but only one metabolite, of apparently many, was identified. The use pattern and consequent negligible residues in plants did not warrant studies in nuninants and poultry.

Triazoxide is very stable in water with extrapolated DT₅₀ values of well over 1 year at pH 4 and 7, and 23 days at pH 9. Aqueous photolysis is expected to be more important under environmental conditions; the DT₅₀ was 2-14 days at latitude 50" depending on the season. On a silica surface, triazoxide was 95% degraded in 7 days when irradiated with a fluorescent lamp. Details of the products were not reported.