69304-47-8

(E)-5-(2-Bromovinyl)-2'-deoxyuridine is an thymidine analogue and acts as an anti-viral by inhibiting DNA plymerase.

White solid

It is used as pharmaceutical intermediate.

This halogenated nucleoside (FW = 333.14 g/mol), also known as brivudin and 5-[ (E) -2-bromoethenyl]-2’-deoxyuridine, is an antiherpetic agent that inhibits viral DNA polymerase. BvdU is a highly potent and selective inhibitor of herpes simplex virus type 1 and varicella-zoster virus infections. Target (s) : DNA polymerase, viral, via the 5’-triphosphate ; HSV-1 replication ; 5’ nucleotidases; dTMP kinase, or thymidylate kinase ; deoxynucleoside kinase, also alternative substrate; thymidine kinase.