ChemicalBook CAS DataBase List 68238-35-7

68238-35-7

Name	KERATIN
CAS	68238-35-7
EINECS(EC#)	269-409-1
MDL Number	MFCD00131434

Chemical Properties

Definition	A class of natural fibrous proteins occurring in vertebrate animals and humans, they are characterized by their high content of several amino acids, especially cystine, arginine, and serine. They are generally harder than the fibrous collagen group of pro
density	1.00 g/mL at 20 °C
storage temp.	2-8°C
form	urea solution
Odor	Characteristic, slight
Uses	keratin is a surface-protective agent with film-forming and moisturizing action. Keratin is often used in cosmetics for its moisture-retention and protective effect. less more
CAS DataBase Reference	68238-35-7
EPA Substance Registry System	Keratins (68238-35-7)

Safety Data

Hazard Codes	Xn,B
Risk Statements	22-52/53 less more
Safety Statements	24/25-61 less more
WGK Germany	3

Raw materials And Preparation Products

Hazard Information

Agricultural Uses

Fibrous proteins are generally insoluble in water and consist of long, coiled strands or flat sheets which have strength and elasticity. Keratin and collagen come in this category. Keratin is present in hair and wool. It is characterized by the high contents of several amino acids, especially cystine, arginine and serine. Keratins are generally harder than the fibrous collagen. Keratins are insoluble in organic solvents, but absorb and hold water.

General Description

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the ′Mediator-like′ protein complexes and the basal transcription machinery. (provided by RefSeq)

Biochem/physiol Actions

Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.

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