Chemical Properties
Yohimbine hydrochloride is white to slightly yellow powder
Uses
Pharmacological probe for the study of a2-adrenoceptor.
Uses
Yohimbine hydrochloride(65-19-0) is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenegic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure.
General Description
Yohimbine hydrochloride is an indole alkaloid derived from the tree bark. It is an antagonist of α2-adrenergic receptors in the brain, reducing the effects of xylazine, which is an α2-adrenergic agonis.
Biochem/physiol Actions
Yohimbine is derived from the Coryanthe yohimbe tree cortex. It is an alkaloid. Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenergic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure. It is useful in treating erectile dysfunction and promotes sexual functioning.
Veterinary Drugs and Treatments
Yohimbine is indicated to reverse the effects of xylazine in dogs, but
it is being used clinically in several other species as well.
Yohimbine may be efficacious in reversing some of the toxic effects
associated with other agents (e.g., amitraz) and can be used
prophylactically before amitraz dips.