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63612-50-0

Name Nilutamide
CAS 63612-50-0
Molecular Formula C12H10F3N3O4
MDL Number MFCD00864670
Molecular Weight 317.22
MOL File 63612-50-0.mol

Chemical Properties

Appearance Crystalline Solid
Melting point  1490C
density  1.463±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  Very slightly soluble in water, freely soluble in acetone, soluble in anhydrous ethanol.
form  solid
pka 7.59±0.70(Predicted)
color  Light yellow to yellow
Usage Nonsteroidal antiandrogen. Antineoplastic (hormonal)
InChIKey XWXYUMMDTVBTOU-UHFFFAOYSA-N
History The second nonsteroidal anti-androgen to be marketed was nilutamide. It was discovered from a series of flutamide analogues at Roussel Uclaf (now Sanofi) in the 1970s using a rat prostate assay determining the inhibition of androgen uptake.The investigational compound code was RU 23908. Its structure is closely related to hydroxyflutamide, particularly under the assumption that the α-hydroxyamide engages in an internal hydrogen bond when bound to the AR LBD. The hydantoin moiety of nilutamide mimics the active conformation of hydroxyflutamide.
Like flutamide, nilutamide blocks the action of androgens originating from both testis and adrenal. It also has neither agonist nor any other hormonal activity. Nilutamide has an elimination half-life of approximately 2 days in patients, which is significantly longer than that of flutamide. Thus, a single oral dose of 150 mg daily was feasible.
CAS DataBase Reference 63612-50-0(CAS DataBase Reference)

Safety Data

Hazard Codes  T
Risk Statements 
R60:May impair fertility.
R25:Toxic if swallowed.
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  NI9453300
HS Code  2933210000

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