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60755-80-8

Name O-DESMETHYLGALANTHAMINE
CAS 60755-80-8
Molecular Formula C16H19NO3
MDL Number MFCD07369289
Molecular Weight 273.33
MOL File 60755-80-8.mol

Chemical Properties

Appearance Pale Yellow Powder
Melting point  227-230°C (dec.)
Boiling point  451.9±45.0 °C(Predicted)
density  1.37±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO: soluble
form  A solid
pka 9.39±0.40(Predicted)
color  White to off-white
Uses
Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.
CAS DataBase Reference 60755-80-8

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