4551-59-1

Fenalamide,ZYF Pharm Chemical

Relaxant (smooth muscle).

ChEBI: Fenalamide is a member of acetamides.

To a solution of 25.5 g of phenylethylmalonic acid ethyl ester chloride in 100 ml of anhydrous benzene 5.3 g of anhydrous sodium carbonate are added followed by 11.6 g of N,N-diethylethylenediamine in small portion. After the spontaneous heat evolution has subsided the mixture is refluxed for 2 hours until the evolution of carbon dioxide ceases. After cooling the mixture is allowed to stand for some hours, the precipitated sodium chloride is removed by filtration. The filtrat is evaporated to dryness in vacuo and the residue distilled at 182-188°C/3 mm Hg.
The phenylethylmalonic acid (diethyl amino) ethylamide ethyl ester (free base) is converted in hydrochloride by bubbling hydrogen chloride into a diethyl ether solution of the free base; melting point 71-74°C.

Spasmolytic, Smooth muscle relaxant