Originator
Tacaryl ,Westwood,US,1960
Definition
ChEBI: Methdilazine is a phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. It has a role as a histamine antagonist, a cholinergic antagonist and an antipruritic drug. It is a member of phenothiazines and a N-alkylpyrrolidine.
Manufacturing Process
10.8 parts of 10-(1-methyl-3-pyrrolidylmethyl) phenothiazine (prepared from 1-methyl-3-pyrrolidylmethyl chloride by reaction with phenothiazine) in 80 parts of 99% isopropyl alcohol were treated with a solution of 1.33 parts of hydrogen chloride in 30 parts of the same solvent. The clear light yellow solution soon deposited white crystals of the acid addition salt. After cooling overnight at 0°C, the crystalline product was collected on a filter, washed with 99% isopropyl alcohol and anhydrous ether and then dried in a vacuum oven at 95°C. Yield 10.4 parts, MP 187.5° to 189°C.
Brand name
Tacaryl (Westwood-Squibb).
Therapeutic Function
Antipruritic
General Description
Crystals.
General Description
Methdilazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine (Tacaryl), is a light-tan crystallinepowder that has a characteristic odor and is practicallyinsoluble in water. Methdilazine, as the free base, isused in chewable tablets because its low solubility in watercontributes to its tastelessness. Some local anesthesia of thebuccal mucosa may be experienced if the tablet is chewedand not swallowed promptly.
Reactivity Profile
METHDILAZINE (200 MG)(1982-37-2) is sensitive to light. .
Health Hazard
SYMPTOMS: Symptoms of exposure to METHDILAZINE (200 MG) may include drowsiness, hypotension, tachycardia, dryness of the mouth, nausea, nasal congestion, fever and tremors.
Fire Hazard
Flash point data for METHDILAZINE (200 MG) are not available. METHDILAZINE (200 MG) is probably combustible.
