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Ald-CH2-PEG5-azide is a click chemistry crosslinker containing an azide group and an aldehyde group. The azide group enables PEGylation via Click Chemistry. PEG5 arm increases solubility in aqueous media. The aldehyde group reacts with amines and the N-terminal of peptides and proteins to form an imine containing a C=N double bond, which can be further reduced.

Ald-CH2-PEG5-azide is a non-cleavable ADC linker containing 5-unit PEG that can be used to synthesize antibody drug conjugates (ADCs).

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